A number of case reports have implicated ephedrine alkaloids as the cause of serious adverse health effects in isolated individuals- including but not limited to heart attack, stroke, seizures, and even death. Ephedrine ih-fed-rin is one of the four active components of the herb Ephedra. It is able to induce fat loss via increasing the amount of fat available for fuel as well as by increasing heat expenditure.
Ephedrine also interacts with muscle cells, increasing heat expenditure in them as well as fat cells. It can also prevent the breakdown of muscle tissue to a small degree. Ephedrine is highly synergistic with caffeine , and for this reason is commonly found in something called an ECA stack Ephedrine, Caffeine , and Aspirin. Side effects include an increase in blood pressure that goes away with cessation and increases in some blood parameters glucose , insulin that also go away with cessation of use.
It has been reported to be a hyperstimulant when taken in doses above what is recommended. Ephedrine is well studied and a fairly reliable compound for short- to medium-term weight loss less than 6 months and mild performance improvements, usually in trained individuals.
However, it does not work under all situations; longer-term weight loss and effects in untrained individuals have not been studied much and sometimes produce negative results. While it has been implicated in weight reduction independent of exercise and diet changes, efficacy is maximized with minimal side-effects when ephedrine is combined with diet and exercise. Learn what supplements to take for your specific health goals with the Examine Supplement Guides. Want a deeper look at the research?
Examine Members get full access to the comprehensive research database, monthly study summaries, and the latest in-depth analysis. In an ECA stack , ephedrine is dosed at mg for three doses taken throughout the day. Human studies have found success with ephedrine in isolation on fat metabolism with doses of mg thrice a day. The higher range mg may be too stimulatory for some, and can induce headaches or light hand tremors. Ephedrine tends to be consumed with xanthine compounds like caffeine and sometimes with Aspirin.
The combination of Ephedrine and caffeine is shown repeatedly to be highly synergistic. Become an Examine Member to get access to the latest research. Understand the whole body of nutrition and supplement evidence at a glance.
The Human Effect Matrix summarizes human studies to tell you what effects Ephedrine has on your body, how much evidence there is, and how strong these effects are. Confounded with the inclusion of caffeine [3] [4] [5] [6] [7] [8] [9]. Confounded with both aspirin and caffeine the ECA stack [10]. To unlock the full archives of our Study Database and research analyses, become an Examine Member today.
Methylxanthines such as caffeine and theophylline a component of green tea. Ephedrine can also increase dopamine levels in the brain, and caution should be taken pairing ephedrine with MAOIs such as yohimbine. Ephedrine should only be used under the supervision of a Medical Doctor, especially if pre-existing cardiac complications exist, due to potentially serious adverse effects.
The legal status of ephedrine varies by country and is a banned substance by certain sports agencies. Since the ban on Ephedra-containing products, many Ephedra-free supplements have appeared on the market. Many manufacturers substitute other botanicals, such as bitter orange, in place of Ephedra. Ephedrine-free supplements often incorporate more than one source of caffeine. The caffeine content is typically higher than that of coffee or soft drinks.
But despite being Ephedra-free, these products can cause adverse effects similar to those of Ephedra-containing products. If you do decide to purchase an Ephedra-free alternative, be sure to review the labels to see if caffeine content is listed. This amount of caffeine is roughly equal to four or five cups of coffee.
Other alternative weight loss supplements include green tea extract EGCG and glucomannan. These supplements typically carry more mild side effects, such as bloating or diarrhea. Although ECA stacks may be a quick way to drop a few pounds or feel alert, they can wreak havoc on your overall health. ECA stacks provide stimulation, or fake energy. They can mask the real underlying reasons for low energy. Healthy eating and regular exercise remain the safest way to successfully lose weight and keep it off.
Ephedra gained popularity as a weight loss supplement in the s, but safety concerns arose. A novel interface could help our brains communicate using radio waves. Tea contains several stimulant substances, including caffeine, theobromine, theophylline and L-theanine. This means you need more and more of them if you are going to get the same effect.
For instance, clenbuterol , generally is less efficient around four to six weeks of continuing use. This is the main reason why stimulants should be on a cycle. They will be effective for longer, especially when it comes to weight loss goals. The cycles allow you to reset your body so you can be more responsive to the stimulants. However, ephedrine works a bit different. It is best to be safe when taking ephedrine and take at least one week off every month to month and a half. If you are using caffeine along with ephedrine, you should cycle off that too.
There are many health concerns when it comes to taking ephedrine. This is why supplement companies are not allowed to add it in as an ingredient. Due to this fact, in the United States, the only products that can contain ephedrine are cold, allergy, and asthma medications such as Primatene and Bronkaid. In addition, there are limits on the amount of ephedrine that someone can purchase each time.
This is because methamphetamine can be manufactured from larger amounts of this medication. The majority of sports organizations ban ephedrine use by their athletes as well. The reason for this is because it could enhance their performance while they are playing the sport. Synephrine is a type of natural compound that is extracted from a fruit.
The fruit is quite bitter. The one thing to note is that synephrine is similar chemically to ephedrine, so there are similar effects. Research shows that one dose of fifty milligrams of synephrine may increase metabolism by about sixty-five calories in seventy-five minutes.
When it is mixed with hesperidin and naringin, two n atural molecules , it rises to around one hundred and eighty calories. This might not seem like a lot for many people. However, the equivalent would be around twenty minutes of jogging.
This would be around one thousand and three hundred calories burned each week. Synephrine has been shown to help people lose what is called stubborn fat.
This is because it inhibits cellular mechanisms that stop the body from burning fat. In addition, synephrine has been shown to increase thermic effects from food which raises the energy expenditure after digesting it.
Synephrine has also been shown to help reduce appetite too. Synephrine has been shown to be safer than ephedrine. This is why synephrine is often considered to be the safest of weight loss supplements on the market. If you would like to lose weight faster without taking something that has potentially dangerous side effects, synephrine would be a better option. Many fat burning supplements have synephrine in them.
Another question that often arises surrounding ephedrine use is whether someone can become addicted to it or not. The answer, for the most part, is yes. There have been people who have become addicted to ephedrine.
There are even some people who have overdosed and died from using it. Since this is a drug that helps people lose weight, many people are under the impression that if they take more of it, they can lose weight even faster.
The problem is this can lead to some severe side effects or even death. If you have become addicted to ephedrine, you can get into an addiction treatment program. If you need treatment for an ephedrine addiction, you can call into a treatment program today. The first step will be to answer questions and talk to them about your addiction. You can let them know how long you have been taking ephedrine, how you became addicted to it, and the severity of your addiction.
Once you get enrolled into a program, you can start with the detox program. This will help you get the ephedrine out of your system. The facility will make you a plan for recovery.
One analysis of 52 different clinical trials found no serious adverse events such as death or heart attack in studies on ephedrine — with or without caffeine Yet, the same analysis found these products were associated with a two- to threefold increased risk of nausea , vomiting, heart palpitations, and psychiatric problems.
Additionally, when individual cases were examined, several deaths, heart attacks, and psychiatric episodes were potentially linked to ephedra Based on the evidence, potential safety concerns were significant enough to prompt legal action in the United States and elsewhere 1. While some individual studies did not demonstrate serious side effects of ephedra or ephedrine consumption, mild to highly concerning side effects became apparent upon examination of all available research. While the ephedra herb and products like ma huang tea are available for purchase, dietary supplements containing ephedrine alkaloids are not.
Some ephedrine-containing medications are still available over the counter, though regulations on the purchase of these products can vary by state. For this reason, some dietary supplement manufacturers will market weight loss products that contain other compounds found in ephedra, but not ephedrine alkaloids.
These products may not have the safety concerns observed for products containing ephedrine — but they may also be less effective.
While some countries outside of the United States have also banned ephedrine-containing products, the specific regulations vary. Dietary supplements containing ephedrine alkaloids were banned by the FDA in Medications containing ephedrine and the ephedra plant are still available for purchase, though regulations may vary by location.
Ephedrine, one of the main components in ephedra, can boost metabolism and cause weight loss — especially in combination with caffeine. Still, due to safety concerns, dietary supplements containing ephedrine — but not necessarily other compounds in ephedra — are currently banned in the United States and elsewhere. Your metabolism determines how many calories you burn each day. Here are 9 easy ways to boost your metabolism, backed by science.
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